processor 50 of imd 16 Search Results


dna elution buffer  (Zymo Research)
95
Zymo Research dna elution buffer
Dna Elution Buffer, supplied by Zymo Research, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human cathepsin h  (Athens Research)
90
Athens Research human cathepsin h
IC 50 Values and Selectivity Indices of Gallinamide A ( 1 ) for Cathepsins L, V, B, and H.
Human Cathepsin H, supplied by Athens Research, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hiprep 16 60 sephacryl s 300  (GE Healthcare)
96
GE Healthcare hiprep 16 60 sephacryl s 300
IC 50 Values and Selectivity Indices of Gallinamide A ( 1 ) for Cathepsins L, V, B, and H.
Hiprep 16 60 Sephacryl S 300, supplied by GE Healthcare, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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jak2 inhibitor pacritinib  (Selleck Chemicals)
93
Selleck Chemicals jak2 inhibitor pacritinib
IC 50 Values and Selectivity Indices of Gallinamide A ( 1 ) for Cathepsins L, V, B, and H.
Jak2 Inhibitor Pacritinib, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dpo72004b fast oscilloscope  (Tektronix inc)
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Tektronix inc dpo72004b fast oscilloscope
IC 50 Values and Selectivity Indices of Gallinamide A ( 1 ) for Cathepsins L, V, B, and H.
Dpo72004b Fast Oscilloscope, supplied by Tektronix inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sphingomyelin  (Croda International Plc)
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Croda International Plc sphingomyelin
IC 50 Values and Selectivity Indices of Gallinamide A ( 1 ) for Cathepsins L, V, B, and H.
Sphingomyelin, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sirnas for pgrmc1, myc, eif2ak1, eif2ak2, eif2ak3, and eif2ak4 as well as negative control sirna  (Shanghai GenePharma)
90
Shanghai GenePharma sirnas for pgrmc1, myc, eif2ak1, eif2ak2, eif2ak3, and eif2ak4 as well as negative control sirna
IC 50 Values and Selectivity Indices of Gallinamide A ( 1 ) for Cathepsins L, V, B, and H.
Sirnas For Pgrmc1, Myc, Eif2ak1, Eif2ak2, Eif2ak3, And Eif2ak4 As Well As Negative Control Sirna, supplied by Shanghai GenePharma, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pgrmc1 rabbit polyclonal antibody  (Proteintech)
93
Proteintech pgrmc1 rabbit polyclonal antibody
Fig. 5 | <t>PGRMC1</t> activated PERK/p-eIF2α axis, which contributed to the reduced level of c-Myc. A Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with siCtrl or siPERK. The indicated proteins were detected by Western Blot. B Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with the treatment of PERK inhibitors (iPERK-1 and iPERK-2). The indicated proteins were detected. C Huh7 and Huh1 cells were transfected with siCtrl or siPERK with or without the tunicamycin treatment. The indicated proteins were detected. D Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with siCtrl or siPERK and the indicated proteins were detected. E Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with the treatment of PERK
Pgrmc1 Rabbit Polyclonal Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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serva blue g-250  (SERVA Electrophoresis)
90
SERVA Electrophoresis serva blue g-250
Fig. 5 | <t>PGRMC1</t> activated PERK/p-eIF2α axis, which contributed to the reduced level of c-Myc. A Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with siCtrl or siPERK. The indicated proteins were detected by Western Blot. B Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with the treatment of PERK inhibitors (iPERK-1 and iPERK-2). The indicated proteins were detected. C Huh7 and Huh1 cells were transfected with siCtrl or siPERK with or without the tunicamycin treatment. The indicated proteins were detected. D Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with siCtrl or siPERK and the indicated proteins were detected. E Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with the treatment of PERK
Serva Blue G 250, supplied by SERVA Electrophoresis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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failsafe premix g buffer  (Epicentre Biotechnologies)
90
Epicentre Biotechnologies failsafe premix g buffer
Fig. 5 | <t>PGRMC1</t> activated PERK/p-eIF2α axis, which contributed to the reduced level of c-Myc. A Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with siCtrl or siPERK. The indicated proteins were detected by Western Blot. B Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with the treatment of PERK inhibitors (iPERK-1 and iPERK-2). The indicated proteins were detected. C Huh7 and Huh1 cells were transfected with siCtrl or siPERK with or without the tunicamycin treatment. The indicated proteins were detected. D Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with siCtrl or siPERK and the indicated proteins were detected. E Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with the treatment of PERK
Failsafe Premix G Buffer, supplied by Epicentre Biotechnologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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source 15q  (GE Healthcare)
96
GE Healthcare source 15q
Fig. 5 | <t>PGRMC1</t> activated PERK/p-eIF2α axis, which contributed to the reduced level of c-Myc. A Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with siCtrl or siPERK. The indicated proteins were detected by Western Blot. B Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with the treatment of PERK inhibitors (iPERK-1 and iPERK-2). The indicated proteins were detected. C Huh7 and Huh1 cells were transfected with siCtrl or siPERK with or without the tunicamycin treatment. The indicated proteins were detected. D Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with siCtrl or siPERK and the indicated proteins were detected. E Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with the treatment of PERK
Source 15q, supplied by GE Healthcare, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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t4 rna ligase  (New England Biolabs)
96
New England Biolabs t4 rna ligase
Fig. 5 | <t>PGRMC1</t> activated PERK/p-eIF2α axis, which contributed to the reduced level of c-Myc. A Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with siCtrl or siPERK. The indicated proteins were detected by Western Blot. B Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with the treatment of PERK inhibitors (iPERK-1 and iPERK-2). The indicated proteins were detected. C Huh7 and Huh1 cells were transfected with siCtrl or siPERK with or without the tunicamycin treatment. The indicated proteins were detected. D Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with siCtrl or siPERK and the indicated proteins were detected. E Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with the treatment of PERK
T4 Rna Ligase, supplied by New England Biolabs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


IC 50 Values and Selectivity Indices of Gallinamide A ( 1 ) for Cathepsins L, V, B, and H.

Journal: Journal of natural products

Article Title: The Marine Cyanobacterial Metabolite Gallinamide A is a Potent and Selective Inhibitor of Human Cathepsin L

doi: 10.1021/np400727r

Figure Lengend Snippet: IC 50 Values and Selectivity Indices of Gallinamide A ( 1 ) for Cathepsins L, V, B, and H.

Article Snippet: Gallinamide was tested for inhibition of human cathepsin V (100 ng/mL; R&D Systems),human cathepsin B (100 ng/mL; R&D Systems), and human cathepsin H (50 ng/mL; Athens Research and Technology).

Techniques:

Fig. 5 | PGRMC1 activated PERK/p-eIF2α axis, which contributed to the reduced level of c-Myc. A Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with siCtrl or siPERK. The indicated proteins were detected by Western Blot. B Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with the treatment of PERK inhibitors (iPERK-1 and iPERK-2). The indicated proteins were detected. C Huh7 and Huh1 cells were transfected with siCtrl or siPERK with or without the tunicamycin treatment. The indicated proteins were detected. D Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with siCtrl or siPERK and the indicated proteins were detected. E Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with the treatment of PERK

Journal: Nature communications

Article Title: Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation.

doi: 10.1038/s41467-024-55745-2

Figure Lengend Snippet: Fig. 5 | PGRMC1 activated PERK/p-eIF2α axis, which contributed to the reduced level of c-Myc. A Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with siCtrl or siPERK. The indicated proteins were detected by Western Blot. B Huh7 and Huh1 cells were transfected with MYC-HA and HA- PGRMC1 together with the treatment of PERK inhibitors (iPERK-1 and iPERK-2). The indicated proteins were detected. C Huh7 and Huh1 cells were transfected with siCtrl or siPERK with or without the tunicamycin treatment. The indicated proteins were detected. D Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with siCtrl or siPERK and the indicated proteins were detected. E Huh7 and Huh1 cells were transfected with HA-PGRMC1 together with the treatment of PERK

Article Snippet: Nature Communications | (2025) 16:50 15 These antibodies were PGRMC1 Rabbit Polyclonal Antibody (Cat#12990-1-AP, Proteintech, 1:1,000), anti-HA Mouse Monoclonal Antibody (Cat#AE008, Abclonal, 1:1,000), and Alexa Fluor® 594 Calreticulin Rabbit Monoclonal antibody (Cat# ab275343, Abcam, 1:500).

Techniques: Transfection, Western Blot

Fig. 9 | Summary of liver specific genes and PGRMC1 in regulating HCC. The deregulated liver-specific genes (LSGs) in HCC were associated with c-Myc onco- genic pathway activation. The LSG PGRMC1 promoted PERK activation in an ER stress-independent manner, and consequently blocked c-Myc-induced hepatic carcinogenesis. Methods restoring the level of liver specific genes such as PGRMC1 hold the potential of treating or even preventing HCC.

Journal: Nature communications

Article Title: Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation.

doi: 10.1038/s41467-024-55745-2

Figure Lengend Snippet: Fig. 9 | Summary of liver specific genes and PGRMC1 in regulating HCC. The deregulated liver-specific genes (LSGs) in HCC were associated with c-Myc onco- genic pathway activation. The LSG PGRMC1 promoted PERK activation in an ER stress-independent manner, and consequently blocked c-Myc-induced hepatic carcinogenesis. Methods restoring the level of liver specific genes such as PGRMC1 hold the potential of treating or even preventing HCC.

Article Snippet: Nature Communications | (2025) 16:50 15 These antibodies were PGRMC1 Rabbit Polyclonal Antibody (Cat#12990-1-AP, Proteintech, 1:1,000), anti-HA Mouse Monoclonal Antibody (Cat#AE008, Abclonal, 1:1,000), and Alexa Fluor® 594 Calreticulin Rabbit Monoclonal antibody (Cat# ab275343, Abcam, 1:500).

Techniques: Activation Assay